2016-2017 Alzheimer’s and Related Diseases Research Award*

Newport Comparative Biochemical and Behavioral Analysis of the 3xTg-AD Mouse Model of University Alzheimer’s Disease

VCoA*The Virginia Center on Aging which administers the Alzheimer’s and Related Diseases Research Award Fund for the Commonwealth of Virginia, provides seed money to researchers in Virginia to stimulate innovative research into biomedical and psychosocial aspects of dementia, including cell biology, caregiving, and animal modeling.


Newport Comparative Biochemical and Behavioral Analysis of the 3xTg-AD Mouse Model of University Alzheimer’s Disease

Lisa S. Webb, PhD and Darlene A. Mitrano, PhD

Christopher Newport University

The investigators will use bioanalytical techniques and behavioral measures to characterize blood lipid profiles and olfactory abilities in the triple transgenic mouse model of Alzheimer’s Disease (3xTg-AD). They will test the mice at three month intervals over the course of a year and compare results from the 3xTg-AD mice to age- and sex-matched mice without AD to pinpoint when blood lipid profiles are altered and when the declines in olfactory abilities become statistically different. The results of this study will better define the biochemical and behavioral phenotype of the 3xTg-AD mice, an important model used to illuminate how AD develops in humans.

(Dr. Webb may be contacted at (757) 594-7056, lwebb@cnu.edu; Dr. Mitrano may be contacted at (757) 594-8093, darlene.mitrano@cnu.edu.)

 

_________________________________________________________________



More 2016-2017 Funded Projects